This page describes the OME-TIFF file format, created by the Open Microscopy Environment Consortium to combine the strengths of OME-XML and TIFF. The format is described at the OME-TIFF page, where there is also a link to the specification.
Some sample OME-TIFF files are available.
The file extension is .ome.tif or .ome.tiff and the MIME Type is xxxxx.
Linkert, M., Rueden, C. T., Allan, C., Burel, J.-M., Moore, W., Patterson, A., Loranger, B., et al. (2010). Metadata matters: access to image data in the real world. The Journal of cell biology, 189(5), 777–82. doi:10.1083/jcb.201004104