BigTIFF is a TIFF-like image file format, which supports larger files and data structures than does TIFF. It is logically almost identical to TIFF, though it is not compatible with it.
Files begin with
49 49 2B 00 08 00 00 00 (little-endian BigTIFF), or
4D 4D 00 2B 00 08 00 00 (big-endian BigTIFF).
- LibTIFF, starting with version 4.
- Fork of libtiff, apparently unofficial fork of libtiff which originated with Aperio, now part of Leica Biosystems.